Inferring the spatiotemporal DNA replication program from noisy data
نویسندگان
چکیده
منابع مشابه
Inferring the spatiotemporal DNA replication program from noisy data.
We generalize a stochastic model of DNA replication to the case where replication-origin-initiation rates vary locally along the genome and with time. Using this generalized model, we address the inverse problem of inferring initiation rates from experimental data concerning replication in cell populations. Previous work based on curve fitting depended on arbitrarily chosen functional forms for...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2014
ISSN: 1539-3755,1550-2376
DOI: 10.1103/physreve.89.032703